Group Examples Action Side effects Uses / Info Resistance Broad G+ G- Anaerobes Sulphonamides folic acid inhibitor Sulfasalazine, sulfadiazine Static Nausea, vomiting headaches, hypersensitivity, bone marrow depression, hepatitis Rarely used due to resistance. Allergic reactions common Useless in infections with ‘pus’ Widespread ? ? ? ? Trimethoprim folic acid inhibitor Trimethoprim Static Nausea, vomiting, skin rashes, megoblastic anaemia resulting from folate deficiency (give supplements) ...