AR and TLR4 labeled with dual-color QDs

Abstract: Diabetes is one of the major chronic diseases diagnosed worldwide with a common complication of diabetic nephropathy (DN). Read this original research and sign up to receive International Journal of Nanomedicine here: http://www.dovepress.com/articles.php?article_id=21823
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Figure 2 The expression of aldose reductase in COS-7 cells transfected with (A) the plasmid of pHAR and (B) empty vector by immunohistochemistry.

Figure 2 The expression of aldose reductase in cells transfected with (A) the plasmid of pHAR and (B) empty vector by immunohistochemistry.

Figure 3 Quantum dot (QD)-based immunofluorescence of aldose reductase (AR) in COS-7 cells transfected with (A and B) plasmid pHAR and (C) empty vector.

Figure 3 Quantum dot (QD)-based immunofluorescence of aldose reductase (AR) in cells transfected with (A and B) plasmid pHAR and (C) empty vector.

Figure 6 The expression of aldose reductase (AR) stained by 3,3′-diaminobenzidine (DAB) and quantum dots with the emission wavelength of 605 nm conjugated to streptavidin (QDs-605-SA) in rat renal tissues. (A, B, E, and F) Normal rat tissue; (C, D, G, and H) diabetic rat tissue.

Dual-color immunofluorescent labeling with quantum dots of the diabete

Figure 7 Multiplexed quantum-dot (QD) imaging of aldose reductase (AR) and Toll-like receptor 4 (TLR4) expressed in the kidneys of diabetic rats.

Figure 7 Multiplexed quantum-dot (QD) imaging of aldose reductase (AR) and Toll-like receptor 4 expressed in the kidneys of diabetic rats.

Figure 1 Agarose gel (1%) electrophoresis of (A) quantum dot (QD)–anti-aldose reductase (AR) conjugates and (B) QD–anti-Toll-like receptor 4 (TLR4) conjugates.

Figure 1 Agarose gel electrophoresis of (A) quantum dot (QD)–anti-aldose reductase (AR) conjugates and (B) QD–anti-Toll-like receptor 4 conjugates.

Figure 4 Hematoxylin and eosin staining of the renal cortex of (A) normal rats and (B) diabetic rats.

Figure 4 Hematoxylin and eosin staining of the renal cortex of (A) normal rats and (B) diabetic rats.

Figure 5 Distribution of Toll-like receptor 4 (TLR4) protein in the renal tissues of (A–C) normal rats and (D–F) diabetic rats identified with immunohistochemistry (IHC) and quantum dot (QD)-IHC.

Figure 5 Distribution of Toll-like receptor 4 protein in the renal tissues of (A–C) normal rats and (D–F) diabetic rats identified with immunohistochemistry (IHC) and quantum dot (QD)-IHC.

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