Nanoparticles for oral delivery of acid-labile lansoprazole

Abstract: The aim of this study was to develop nanoparticles for oral delivery of an acid-labile drug, lansoprazole (LPZ), for gastric ulcer therapy. Read this original research and sign up to receive International Journal of Nanomedicine here: http://www.dovepress.com/articles.php?article_id=22230
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Figure 5 Endoscopic view, histology, and confocal imaging of rat esophageal mucosa before NP administration.

Figure 5 Endoscopic view, histology, and confocal imaging of rat esophageal mucosa before NP administration.

Figure 1 Transmission electron micrographs (50,000×) and particle size distribution of ERS ERSNPs-LPZ (A, C) and PLGA NPs-LPZ (B, D).

Application of nanoparticles for oral delivery of acid-labile lansopra

Figure 2 Release of LPZ from (■) ERS NPs-LPZ and (▲) PLGA NPs-LPZ in pH 7.4 phosphate-buffered solution (n=3). Abbreviations: LPZ, lansoprazole;

Application of nanoparticles for oral delivery of acid-labile lansopra

Figure 3 Fluorescence microscopic images and biodistribution of nanoparticles.

Figure 3 Fluorescence microscopic images and biodistribution of nanoparticles.

Figure 4 Cellular uptake efficiency (%) and confocal microscopic images of Caco-2 cells.

Figure 4 Cellular uptake efficiency (%) and confocal microscopic images of cells.

Figure 5 LPZ concentration versus time profiles in Wistar rats with induced ulcers, after oral administration of (A) LPZ solution (●), (B) ERS NPs-LPZ (■), and PLGA NPs-LPZ (▲) (LPZ 5 mg/kg), respectively (n=4).

Application of nanoparticles for oral delivery of acid-labile lansopra

Figure 6 Photographs of stomach and ulcer index.

Application of nanoparticles for oral delivery of acid-labile lansopra

Figure 7 Histopathological images of healthy tissue and healing ulcer tissues.

Figure 7 Histopathological images of healthy tissue and healing ulcer tissues.

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