Drive Angry Piper is played by Amber Heard. She is holding "The Godkiller" pepperbox gun which has the power to completely destroy one's soul. John Milton, played by Nicolas Cage, had stolen this gun from Satan when he broke out of Hell.
When Reagen gets chocked by some of the good guys. She begs fir mercy saying they won't want to do this, but they take her back to their house to discuss this later and lock her in the basement where she can't escape.